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Home - Products - Immunology/Inflammation - Lipoxygenase - CJ-13,610 hydrochloride

CJ-13,610 hydrochloride

CAS No. 179420-27-0

CJ-13,610 hydrochloride( —— )

Catalog No. M27863 CAS No. 179420-27-0

CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CJ-13,610 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.
  • Description
    CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological effects of LTs.(In Vitro):In intact human polymorphonuclear leukocytes (PMNL), challenged with the Ca(2+)-ionophore A23187, CJ-13,610 hydrochloride potently suppressed 5-LOX product formation with an IC50 of 70 nM. In transfected HeLa cells, CJ-13,610 hydrochloride only slightly discriminated between phosphorylatable wild-type 5-LOX and a 5-LOX mutant that lacks phosphorylation sites.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    STAT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    179420-27-0
  • Formula Weight
    429.96
  • Molecular Formula
    C22H24ClN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.O=C(N)C1(C=2C=CC=C(SC3=CC=C(C=C3)N4C=CN=C4C)C2)CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ayyiliath M Sajith, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.
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